Breast uptake of bone agents is a common finding, but it is nonspecific, as it is seen in normal breasts as well as in those with benign and malignant disease . The exact mechanism of uptake is uncertain, but it has been related to high tissue calcium levels or to binding to receptor site of acid phosphatase.
Breast Uptake
- Amyloidosis (ref)
- Breast carcinoma (ref)
- Fat necrosis
- Gynecomastia
- Hematoma
- Lactation
- Mastitis
- Mastoplasia
- Normal (ref)
- Osteosarcoma
- Post mastectomy
Normal breast.
Bone scintigram shows bilateral symmetrical uptake in normal breasts.
Breast carcinoma.

The bone scintigram shows intense softtissue uptake in a large carcinoma of the left breast. Calcifications in the mass were present on xeromammogram.