SPLEEN

The most common cause of splenic localization of bone tracers is sickle cell disease . This is probably due to both calcification of infarcted splenic tissue and iron deposition in the infarcted tissue, (iron deposits have affinity for the diphosphonate complex). Splenic uptake also can be seen in thalassemia and hemosiderosis.

Splenic Uptake

Angiosarcoma
Aplastic anemia
Autoimmune hemolitic anemia (ref)
Glucose-6-dehydrogenase deficiency
Hemangioma (ref)
Hemosiderosis (ref)
Iohexol injection (ref)
Leukemia
Lymphoma
Sickle cell disease (ref)
Sickle-thalassemia
Splenic arthery calcifications
Subcapsular hematoma

Splenic Infarct

Sickle cell disease.

The bone scintigram demonstrates uptake in the spleen. Note foci of increased accumulation in multiple rib infarcts.

Splenic infarct

Sickle cell disease.

The bone scintigram demonstrates uptake in the spleen.